Full time faculty

Adjunct professor

Chair professor

Administration

Liang Ge

Liang GE, Ph.D.

Principal Investigator, Assistant Professor

Awards

NIH Pathway to Independence Award (K99/R00) (2015-2017)

Jane Coffin Child Foundation Fellowship (2013-2015)

Human Frontier Science Program Fellowship (2012)

 

CV

2001-2005     B.S.                       

            Shandong Normal University

2005-2011     Ph.D.                      

            Institute of Biochemistry and Cell Biology, SIBS, CAS

2011-2015     Postdoctoral Fellow                     

            University of California, Berkeley

2015-2017     Research Specialist           

            University of California, Berkeley

2017-             Assistant Professor/Principal Investigator

            School of Life Sciences, Tsinghua University and Center for Life Sciences

 

Research Interest

Autophagy is a key mechanism for clearance of damaged cellular components, which is tightly related to aging and human diseases. We employ cutting-edge techniques of cell biology and biochemistry to study the mechanisms and functions of autophagy. Our major focus is the mechanism of autophagic membrane formation, its role in degrading toxic protein aggregates and unconventional secretion. In addition, we are also interested in the involvement of autophagy in maintaining homeostasis and the pathogenesis of human disease, e.g. cancer and neurodegeneration.

Selected Publications

1. Liang Ge*, Min Zhang, Sam Kenny, Anandita Mathur, Dawei Liu, Miharu Maeda, Kota Saito, Ke Xu, and Randy Schekman. Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis. EMBO Report (2017) 18(9):1586-1603. * Corresponding author.

2. Livia W Brier, Min Zhang, Liang Ge*. Mechanistically dissecting autophagy: insights from in vitro reconstitution. J Mol Biol (2016) 8;428(9 Pt A):1700-13.*Corresponding author

3.Liang Ge, Livia Wilz and Randy Schekman. Biogenesis of autophagosomal precursors for LC3 lipidation from the ER-Golgi intermediate compartment. Autophagy (2015) 11(12):2372-4

4.Liang Ge, Min Zhang and Randy Schekman. Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment. eLife (2014) Nov 28; 3:e04135.

5.Liang Ge, Sulochanadevi Baskaran, Randy Schekman and James H Hurley. The protein-vesicle network of autophagy. Curr Opin Cell Biol (2014) 29C:18-24.

6. Liang Ge and Randy Schekman. The ER-Golgi intermediate compartment feeds the phagophore membrane. Autophagy (2013) 10(1):170-2

7. Liang Ge, David Melville, Min Zhang and Randy Schekman. The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. eLife (2013) Aug 6; 2:e00947. Selected for F1000Prime and highlighted by Daniel Klionsky [Amélie Bernard and Daniel J Klionsky. Defining the membrane precursor supporting the nucleation of the phagophore. Autophagy (2014) 10(1):1-2].

8. Liang Ge, Wei Qi, Li-Juan Wang, Hong-Hua Miao, Yu-Xiu Qu, Bo-Liang Li and Bao-Liang Song. Flotillins play an essential role in Niemann-Pick C1 Like 1-mediated cholesterol uptake. Proc Natl Acad Sci USA (2011) 108(2):551-556

9. Liang Ge, Jing Wang, Wei Qi, Hong-Hua Miao, Jian Cao, Yu-Xiu Qu, Bo-Liang Li and Bao-Liang Song. The cholesterol absorption inhibitor Ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metabolism (2008) 7:508-519. Selected for F1000Prime; Featured Article; Commented in Cell Metabolism (2008) 7:469-471

10.Jin-Hui Zhang*, Liang Ge*, Wei Qi, Liqing Zhang, Hong-Hua Miao, Bo-Liang Li, Maojun Yang and Bao-Liang Song. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J Biol Chem (2011) 286(28):25088-097            *Equal contribution

11.Bei-Bei Chu*, Liang Ge*, Yang Zhao, Jing Wang, Bo-Liang Li and Bao-Liang Song. Requirement of myosin Vb·Rab11a·Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. J Biol Chem (2009) 284(33):22481-90.  *Equal contribution

 

 

Contact

Telú║+86-10-62789019(lab)      

E-mail: liangge@mail.tsinghua.edu.cn



Tsinghua University,Beijing,China,100084
Tel:+86-10-62788604  Fax:+86-10-62788604  Email:admin-life@biomed.tsinghua.edu.cn