Full time faculty

Adjunct professor

Chair professor


Xianyang Fang

Xianyang Fang, Ph.D.

Principal Investigator

Education and Professional Positions

1998- 2002       Bachelor's degree in Chemistry

                Wuhan University, China

2002-2008       Ph.D. in Biochemistry and Molecular Biology

                Institute of Biophysics

                Chinese Academy of Sciences, China

2009-2015       Research Fellow/Visiting Postdoctoral Fellow

                National Cancer Institute at Frederick

                National Institute of Health, USA

2015           Principal Investigator

               Tenure-track Assistant Professor

               School of Life Sciences, Tsinghua University

Research Area

Our research focuses on the structural biology of non-coding RNAs involved in important biological processes and human diseases. We employ key techniques of  Small Angle X-ray Scattering(SAXS), NMR and X-ray Crystallography, in conjunction with other biophysical, biochemical, computational and molecular biology methods to investigate the structure and function of noncoding RNAs in virus, cancer and neurodegenerative diseases, and their interactions with proteins, RNAs and DNAs. We are also interested in developing novel integrative structural biology methods by combined use of SAXS and other biophysical techniques.

Selected Publications

1.      Xianyang Fang, Jason R. Stagno,Yuba Bhandari,Xiaobing Zuo,Yun-Xing Wang. Small-angle X-ray scattering: a bridge between RNA secondary structures and three-dimensional topological structures. Current Opinion in Structural Biology 2015,30:147-160.

2.      Sujay Subbayya Ithychanda, Xianyang Fang, Maradumane L. Mohan, Liang Zhu, Kalyan C. Tirupula, Sathyamangla V. Naga Prasad, Yun-Xing Wang, Sadashiva Karnik, Jun Qin. A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A. Journal of Biological Chemistry 2015, 290(13):8527-38.

3.      Yi Peng, Joseph E. Curtis, Xianyang Fang, and Sarah A. Woodson. Structural Model of the folded rpoS mRNA leader in complex with Hfq. Proceedings of the Naitonal Academy of Sciences 2014, 111(48): 17134-9.

4.      Alexander Lemak, Bin Wu, Adelinda Yee, Scott Houliston, Hsiau-Wei Lee,  Aleksandras Gutmanas, Xianyang Fang, Maite Garcia, Anthony Semesi,  Yun-Xing Wang, James H. Prestegard, Cheryl H. Arrowsmith. Structural characterization of a flexible two-domain protein in solution based using Small Angle X-ray Scattering and NMR Data. Structure 2014, 22(12):1862-74

5.      Feng-Ming James Chang, Coyne, H. Jerome, Ramirez, Ciro Alberto Cubillas, Pablo Vinuesa Fleischmann, Xianyang Fang, Zhen Ma, Dejian Ma, John D. Helmann, Alejandro García-de los Santos, Yun-Xing Wang, Charles E. Dann III, and David P. Giedroc. Cu(I)-mediated Allosteric Switching in a Copper-sensing Operon Repressor (CsoR). Journal of Biological Chemistry 2014, 289(27):19204-17.

6.      Xianyang Fang# , Jinbu Wang#, Ina P. O’Carroll#, Michelle Mitchell, Xiaobing Zuo, Yi Wang, Ping Yu, Yu Liu, Jason W. Rausch, Marzena A. Dyba, Jørgen Kjems, Charles D. Schwieters, Soenke Seifert, Randall E. Winans, Norman R. Watts, Stephen J. Stahl, Paul T. Wingfield, R. Andrew Byrd, Stuart F. J. Le Grice, Alan Rein*,Yun-Xing Wang*. An unusual topological structure of the HIV-1 rev response element, Cell 2013, 155(3): 594-605.

7.      Moshe Giladi, Itay Friedberg, Xianyang Fang, Reuben Hiller, Yun-Xing Wang,  Daniel Khananshvili. G503 is obligatory for dynamic coupling of regulatory domains in NCX proteins Biochemistry 2012, 51(37):7313-20.

8.      Moshe Giladi, Yeheskel Sasson, Xianyang Fang, Reuben Hiller, Tal Buki, Yun-Xing Wang, Joel Alan Hirsch, Daniel Khananshvili. A common Ca2+-driven interdomain module governs eukaryotic NCX regulation, PLoS One 2012, 7(6): e39985.

9.      George Avvakumov, John Walker, Sheng Xue, Abdellah Allali-Hassani, Abdalin Asinas, Usha Nair, Xianyang Fang, Xiaobing Zuo, Yun-Xing Wang, Keith Wilkinson, Sirano Dhe-Paganon. Two ZnF-UBP domains in isopeptidase T (USP5), Biochemistry 2012, 51(6): 1188-98.

10.  Xianyang Fang, Yingang Feng, and Jinfeng Wang. Favorable contribution of the C-terminal residue K97 to the stability of a hyperthermophilic archaeal [P62A]Ssh10b, Archives of Biochemistry and Biophysics 2009, 481(1):52-8.

11.  Xianyang Fang#, Qiu Cui#, Yufeng Tong, Yingang Feng, Lu Shan, Li Huang, and Jinfeng Wang. A stabilizing a/β-hydrophobic core greatly contributes to hyperthermostability of archaeal [P62A]Ssh10b. Biochemistry 2008, 47(43):11212-21.

12.  Quan Luo#, Xianyang Fang#, Zhiwei Deng, Jinfeng Wang. NMR study of influences of D51N mutation on backbone conformation of hyperthermophilic archaeal [P62A]Ssh10b. Chemical  Journal of Chinese Universities-Chinese 2008,29,546-550.  

# co-first author; *corresponding author


Email: fangxy@mail.tsinghua.edu.cn; fxy@mail.biomed.tsinghua.edu.cn

Tel: +86-10-62771071

Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn