
Xin Liang, Ph.D.
Principal Investigator/Tenure Track Assistant Professor
Education
1999-2003 B.Sc. Shanghai Jiao Tong University
2003-2007 Ph.D. Shanghai Jiao Tong University
2008-2014 Postdoctoral fellow Max-Planck Institute of Molecular Cell Biology and Genetics
2009-2011 "Alexander von Humboldt" Fellow
2015- Principal Investigator/Assistant Professor Tsinghua University
Research Area
We apply biophysical concepts and methods to study the mechanisms underlying the force sensation of cells. The specific research directions are: (1) the molecular basis of mechanotransduction in mechanosensory neurons; (2)the cell biological and molecular mechanisms underlying the selective responses of different mechanosensory cells to different mechanical stimuli; (3) the molecular basis of microtubule dynamics and their contributions in cell morphological control and cell mechanics.
Award
2015- Max-Planck Partner Group Program
Selected Publications
1. Liang X, Madrid J, Howard J, The Microtubule-based Cytoskeleton is a Component of a Mechanical Signaling Pathway in Fly Mechanoreceptors. Biophysical Journal. 2014 Dec 16; 107(12): 2767-74.
2. Liang X, Madrid J, Gärtner R, Verbavatz JM, Schiklenk C, Wilsch-Bräuninger M, Bogdanova A, Stenger F, Voigt A, Howard J, A NOMPC-dependent membrane-microtubule connector is a candidate of the gating spring in fly mechanoreceptors. Current Biology. 2013 May 6; 23 (9):755-63.
3. Liang X, Madrid J, Saleh HS, Howard J. NOMPC, a member of the TRP channel family, localizes to the tubular body and distal cilium of Drosophila campaniform and chordotonal receptor cells. Cytoskeleton. 2011 Jan; 68(1):1-7. (Cover of Vol. 68, Iss. 2, Feb. 2011.)
4. Liang X, Hu XF, Hu J. Dynamic inter-receptor coupling contributes to the consistent open duration of ryanodine receptors. Biophysical Journal. 2009 Jun 17; 96(12): 4826-33.
5. Liang X, Hu XF, Hu J. Dynamic inter-receptor coupling: a novel working mechanism of two dimensional ryanodine receptor array. Biophysical Journal. 2007 Feb 15;92 (4):1215-23.
6. Liang X, Chen K, Fruen B, Hu J, Ma J, Hu X, Parness J., Impaired interaction between skeletal ryanodine receptors in malignant hyperthermia. Integrative Biology, 2009, 1, 533-539.
7. Liang X*, Sun LD and Liu Z, Mechanosensory Transduction in Drosophila Melanogaster. BOOK ISBN: 978-981-10-6525-5. DOI: 10.1007/978-981-10-6526-2. Springer.
8. Liang X*, Howard J, Structural Biology: A Force-Sensitive Ion Channel Springs to Life. Current Biology. 2017 Sep 25;27(18):R1017-R1020.
9. Feng S, Song Y, Shen M, Xie S, Li W, Lu Y, Yang Y, Ou G, Zhou J, Wang F, Liu W, Yan X, Liang X*, Zhou T*. Microtubule-binding protein FOR20 promotes microtubule depolymerization and cell migration. Cell Discovery. 2017 Sep 5;3:17032.
Contact
E-mail: xinliang@mail.tsinghua.edu.cn
Tel: 010-62772563(office) 010-62771231(lab)
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