Full time faculty

Adjunct professor

Chair professor

Administration

Peng Jiang

Peng Jiang

Principal Investigator

 

1999-2003  B.S., Anhui University, School of Life Sciences

2003-2008  Ph.D., University of Science and Technology of China, School of Life Sciences

2008-2013  Postdoc, University of Pennsylvania, Perelman School of Medicine

2013-2014  Research associate, University of Pennsylvania, School of Medicine

2014-      Principal Investigator, Tsinghua University, School of Life Sciences

Research Area

Cancer Metabolism. One of the newly-identified, major biochemical hallmarks of cancer cells is a metabolism switch whereby cancer cells consume more glucose and glutamine than normal tissue, and favor a much less efficient but rapid metabolic mechanism for energy production. Currently, we are interested in how this might happen and how exactly nutrient metabolism is altered by signal transduction changes in cancer cells and what advantages these alterations afford. Understanding these issues will have great value for defining and targeting a therapeutic window for treating cancer.

Selected Publications

1.        Jiang P*, Du W and Wu M*. Regulation of pentose phosphate pathway in cancer. Protein &Cell. (2014) Aug;5(8):592-602. Review article.

2.        Jiang P, Du W and Yang X. Critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation. Cell Cycle. (2013), 12(24): 3720-3726.

3.        Jiang P, Du W and Yang X. p53 and regulation of tumor metabolism. Journal of Carcinogenesis. (2013), 12:21.Review article.

4.        Du W, Jiang P, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M and Yang X. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology. (2013), Aug. 15, 991–1000.

5.        Jiang P, Du W, Mancuso A, Wellen KE, Yang X. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693. 

6.        Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M and Yang X. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. (2011) Mar.13: 310-316.

Contact Information

Email£ºpengjiang@mail.tsinghua.edu.cn

Phone£º010-62786079 (Office) or 010-62783063 (Qing Li, Administrative Assistant)



Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn