Full time faculty

Adjunct professor

Chair professor

Administration

Ding Xue

Ding Xue Ph.D,

Professor,

Cheung Kong Scholar

National Distinguished Scholar (1000-Talent Plan, B category)

Professional overview:

1981-1986                  B.S., University of Science and Technology of China, Hefei, Anhui

1986-1987                 Shanghai Institute of Cell Biology, Chinese Academic of Science

1988-1989                 University of Connecticut Medical School

1989-1993                Ph.D., Columbia University, New York (Advisor: Dr. Martin Chalfie)

1994-1997                 Postdoc. Massachusetts Institute of Technology (Advisor: Dr. Robert Horvitz)

1997-2003                  Assistant Professor, University of Colorado at Boulder  

2003-2007                  Associate Professor (Tenured), University of Colorado at Boulder

2007-present              Professor, University of Colorado at Boulder

2007-2013               Adjunct Chair Professor, School of Life Sciences, Tsinghua University

2013-present             Adjunct Professor, School of Life Sciences, Tsinghua University

2008-2014                  Foreign Adjunct Professor, Karolinska Institutet

Main Research Fields:

We use C. elegans as the major animal model to study regulation, activation and execution of apoptosis, the molecular components and mechanisms that establish and maintain phospholipid asymmetry in biological membranes, the mechanisms underlying the selective elimination of paternal mitochondria during early animal development, the pathogenesis and treatment of liver disease caused by Hepatitis B virus, and human disease caused by abnormal apoptosis and

phospholipid asymmetry.

Selected Publications:

  • Parrish, J., Li, L., Klotz, K., Ledwich, D., Wang, X.D., and Xue, D. (2001).  Mitochondrial endonuclease G is important for apoptosis in C. elegans.  Nature 412, 90-94.
  • Wang, X.C., Yang, C.L., Cai, J.J., Shi, Y.G., and Xue, D. (2002).  Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans.  Science 298, 1587-1592. (Research Article)
  • Parrish, J. and Xue, D. (2003). Functional genomic analysis of apoptotic DNA degradation in C. elegans.  Molecular Cell 11, 987-996.
  • Wang, X.C, Wu, Y.C, Fadok, V., Lee, M.C., Gengyo-Ando, K., Cheng, L.C., Ledwich, D., Hsu, P.K., Chen, J.Y., Chou, B.K., Henson, P., Mitani, S., and Xue, D. (2003).  Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.  Science 302, 1563-1566.
  • Kokel, D., Li, Y.H., Qin, J., and Xue, D. (2006). The non-genotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in C. elegans.  Nature Chemical Biology 2: 338-345.
  • Wang, X.C., Wang, J., Yang, C.L, Gengyo-Ando, K., Gu, L.C., Sun, C.L., Shi, Y., Shi, Y.G., Mitani, S., Xie, X.S., and Xue, D. (2007). "C. elegans Mitochondrial Factor WAH-1 Promotes Phosphatidylserine Externalization in Apoptotic Cells by Activating Phospholipid Scramblase 1".  Nature Cell Biology 9, 541-549.
  • Peden, E., Kimberly, E.L., Gengyo-Ando, K., Mitani, S., and Xue, D. (2007). Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes & Development 21, 2195-3207.
  • Darland-Ransom, M., Wang, X.C., Sun, C.L., Mapes, J., Gengyo-Ando, K., Mitani, S. and Xue, D.* (2008). Role of the C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science 320, 528-531.
  • Breckenridge, D., Kang, B.H., Kokel, D., Mitani, S., Staehelin, A.L., and Xue, D.* (2008). Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell death execution pathways downstream of ced-3 and independent of ced-9. Molecular Cell 31, 586-597.
  • Geng, X., Shi, Y., Nakagawa, A., Yoshina, S., Mitani, S., Shi, Y., and Xue, D.* (2008).  Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by a caspase homolog CSP-3. Nature Structural & Molecular Biology 15, 1094-1101.
  • Nakagawa, A., Shi, Y., Kage-Nakadai, E., Mitani, S., and Xue, D.* (2010). Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease. Science 328, 327-334. (Research Article).
  • Wang, X.C., Li W., Zhao, D.F., Liu, B., Shi, Y., Chen, B.H., Yang, H.W., Guo, P.F., Geng, X., Shang, Z.H., Peden, E., Kage-Nakadai, E., Mitani, S., and Xue, D.* (2010). C. elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nature Cell Biology 12, 655-664.
  • Zhou, Q.H., Li, H.M., and Xue, D.* (2011). Elimination of Paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Research 21, 1662-1669.
  • Mapes, J., Chen, Y.Z., Kim, A., Mitani, S., Kang, B.H., and Xue, D.* (2012). CED-1, CED-7, and TTR-52 act in a pathway to regulate exoplasmic phosphatidylserine expression on apoptotic and phagocytic cells. Current Biology 22, 1267-1275.
  • Geng, X., Harry, B.L., Zhou, Q.H., Skeen-Gaar, R.B., Ge, X., Lee, E.S., Mitani, S., and Xue, D.* (2012a). Hepatitis B Virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in C. elegans. Proc. Natl. Acad. Sci. USA 109: 18465-18470.
  • Geng, X., Huang, C.H., Qin, Y., McComb, J., Yuan, Q., Harry, B.L., Palmer, A., Xia, N.S., and Xue, D.* (2012b). Hepatitis B virus X protein targets Bcl-2 proteins to increase cytosolic Ca2+, required for virus replication and cell death induction. Proc. Natl. Acad. Sci. USA 109, 18471-18476.
  • Chen, Y.Z., Mapes, J., Lee, E.S. and Xue, D.* (2013). Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and PS externalization. Nature Communications 4:2726 doi: 10.1038/ncomms3726.
  • Zhao, P., Zhang, Z., Ke, H.M., Ye, Y.R. and Xue, D.* (2014). Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system. Cell Research 24: 247-250.

Contact

Tel: +86-10-62795276 (lab)      

E-mail: dingxueus@gmail.com



Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn