Full time faculty

Adjunct professor

Chair professor

Administration

Qiaoran Xi

 

Qiaoran Xi, Ph.D

Principal Investigator

1989-1993             B.S.                            Nanjing University, Nanjing

1998-2004             Ph.D.                           New York University Medical Center

2004-2005             Postdoc                           New York University Medical Cente

2006-2013             Postdoc                       Memorial Sloan-Kettering Cancer Center

2013-present     Principle Investigator      School of Life Sciences, Tsinghua University

Main Research Fields:

Our research focuses on studying the molecular mechanism of TGF-β signaling in self-renewal and differentiation of embryonic stem cells. In particular, we are investigating how TGF-β signaling regulates stem cell differentiation epigenetically through Smad2/3-TRIM33 complexes. We are also interested in studying the crosstalk between TGF-β signaling and other signaling pathways in development and tumorigenesis.

Selected Publications:

Aragón E, Goerner N, Xi Q, Lopes T, Gao S, Massagué J and Macias M (2012) Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β pathways. Structure 20(10): 1726-36

Massagué J, and Xi Q. (2012) TGF-β control of stem cell differentiation genes. FEBS Letters 586:1953-8.

Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang L, Liu JX, Kim H, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, and Massagué J. (2011) A poised chromatin platform for TGFβ access to master regulators. Cell 147:1511-24.

Aragón E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massagué J, and Macias M. (2011) A Smad action-turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 25:1275-88.

Alarcón C, Zaromytidou AI*, Xi Q*, Gao S*, Yu J, Fujisawa S, Barlas A, Miller A, Manova-Todorova K, Sapkota G, Pan D, and Massagué J. (2009) CDK8/9 kinases drive Smad transcriptional action and turnover in BMP and TGFβ pathways. Cell 139:757-69. (*These authors contributed equally to this work.)

Xi Q, He W, Zhang XH, Le HV, Massagué J. (2008) Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor β transcriptional program. J Biol Chem. 283:1146-55.

X i Q , Cuesta R, and Schneider RJ. (2005) Regulation of ribosome shunting translation by phosphotyrosine-dependent coupling of adenovirus 100k protein to viral mRNAs. J. Virol. 79:5676-5683.

Xi Q, Cuesta R, and Schneider RJ. (2004) Tethering of eIF4G to Adenoviral 100k protein drives ribosome shunting. Genes Dev. 18:1997- 2009.

Contact£º

Tel£º+86-10-62771605(lab)       Fax£ºN/A

E-mail: xiqiaoran@biomed.tsinghua.edu.cn  Homepage: N/A

 



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