Full time faculty

Adjunct professor

Chair professor


Zhi John Lu

Zhi John Lu   Ph.D.
Principal Investigator

Education and Professional Profile

Year(s) Field of study Position Institution and Location
2011. - Bioinformatics and Genomics PI Tsinghua University, Beijing, China
2008-2011 Bioinformatics Postdoc Yale University, New Haven, CT, US
2003-2008 Biophysics Ph.D. University of Rochester, Rochester, NY, US
1998-2003 Life Sciences B.S. University of Science and Technology of China

Research Interests

  • Identification of epigenetics code and noncoding markers in cancer

  • Prediction and characterization of novel noncoding RNAs in model genomes

  • Structure prediction and functional study of protein-RNA interactions

  • Development of cloud computing algorithms and databases for biological and medical data

Selected Publications:

[1]   Yang Wu1, Binbin Shi1, Xinqiang Ding, Tong Liu, Xihao Hu, Kevin Y. Yip, Zheng Rong Yang, David H. Mathews and Zhi John Lu* (2015) Improved prediction of RNA secondary structure by integrating the free energy model with restraints derived from experimental probing data. Nucleic Acids Research 43(15): 7247-59. (1contributed equally)

[2]   Long Hu, Chao Di, Mingxuan Kai, Yu-Cheng T. Yang, Yang Li, Yunjiang Qiu, Xihao Hu, Kevin Y. Yip, Michael Q. Zhang and Zhi John Lu* (2015) A common set of distinct features that characterize noncoding RNAs across multiple species. Nucleic Acids Research 43(1): 104-114.

[3]   Yu-Cheng T. Yang1, Chao Di1, Boqin Hu1, Meifeng Zhou, Yifang Liu, Nanxi Song, Yang Li, Jumpei Umetsu and Zhi John Lu* (2015) CLIPdb: a CLIP-seq database for protein-RNA interactions. BMC Genomics 16:51 (1contributed equally)

[4]   Chao Di1, Jiapei Yuan1, Yue Wu, Jingrui Li, Huixin Lin, Long Hu, Ting Zhang, Yijun Qi, Mark B. Gerstein, Yan Guo and Zhi John Lu* (2014) Characterization of Stress-responsive lncRNAs in Arabidopsis thaliana by Integrating Expression, Epigenetic and Structural Features. The Plant Journal 80:848–861

[5]   Tan X, Hu L2, Luquette LJ, Gao G, Liu YF2, Qu HJ, Xi RB, Lu ZJ2, Park PJ & Elledge SJ. (2012) Systematic Identification of Synergistic Drug Pairs Targeting HIV. Nature Biotech. 30:1125-1130 (2Lu Lab, School of Life Sciences, Tsinghua University)

[6]   Tan X, Lu ZJ 2, Gao G, Xu QK, Hu L2, Fellmann C, Li MZ, Qu HJ, Lowe SW, Hannon GJ & Elledge SJ. (2012) Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. Proc. Natl. Acad. Sci. U. S. A., 109(3): 869-74 (2Lu Lab, School of Life Sciences, Tsinghua University)

[7]   Lu ZJ1, Yip KY1, Wang G, Shou C, Hillier LW, et al. (2011) Predicting and characterizing non-coding RNA in C. elegans by integrating conservation, secondary structure and high-throughput sequencing and array data. Genome Research 21: 276-2857 (1contributed equally) [modENCODE special issue – Cover Story]

[8]   Gerstein MB 1*, Lu ZJ1, Van Nostrand EL1, Cheng C1, Arshinoff BI1, et al. (2010) Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330(6012): 1775-1787 (1contributed equally, *corresponding authors) [Cover Story]



  • New Century Excellent Talents (2011, Ministry of Education of China)

  • Junior Faculty Award (2011, Tsinghua University)

  • Bayer Investigator Fellowship (2011, Bayer-Tsinghua Joint Research Center)

  • Wallace O. Fenn Award (2009, School of Medicine and Dentistry, U. of Rochester)

  • George V. Metzger Award (2009, Program in Biophysics, Univ. of Rochester)

  • Award for Excellent Student (2001, Top 10% students, Univ. of Sci. & Tech. of China)


Tel./TAX: +86-10-62789217

E-mail: lulab@biomed.tsinghua.edu.cn

Lab page: http://bioinfo.life.tsinghua.edu.cn

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China

Tsinghua University,Beijing,China,100084
Tel:+86-10-62788604  Fax:+86-10-62788604  Email:admin-life@biomed.tsinghua.edu.cn