Full time faculty

Adjunct professor

Chair professor


Junbiao Dai

Junbiao Dai Ph.D.

Principle Investigator


2011-present   Associate professor, School of Life Sciences, Tsinghua Univeristy

2006-2011       Postdoctoral fellow, Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine

2000-2006       Ph.D. , Department of Genetics, Development and Cell Biology, Iowa State University

1997-2000       M.S. , Department of Biological Science and Biotechnology, Tsinghua University

1993-1997       B.S., Department of Intensive Instruction, Nanjing University


Research Interest

The Dai lab uses budding yeast as model organism to study the function of chromatin with emphasis on histone modifications. In addition, his lab is synthesizing the yeast chromosome XII as a part of the international collaborative project (the Sc2.0 project) and developing technologies for synthetic biology.


Selected Publications

1.  Chao Wu, Wei Xiong, Junbiao Dai* and Qingyu Wu*, Genome-based metabolic mapping and 13C flux analysis reveal systematic properties of an oleaginous microalga Chlorella protothecoides, Plant Physiol., 2015 167(2): 586-99. (*Co-corresponding author)

2.  Li Zhao, Junbiao Dai* and Qingyu Wu*, Autophagy-like processes are involved in lipid droplet degradation in Auxenochlorella protothecoides during the heterotrophy-autotrophy transition, Front Plant Sci., 2014, 5: 400. (*Co-corresponding author)

3.  Chunfang Gao, Yun Wang, Yue Shen, Dong Yan, Xi He, Junbiao Dai* and Qingyu Wu*, Oil accumulation mechanisms of the oleaginous microalga Chlorella protothecoides revealed through its genome, transcriptomes, and proteomes, BMC Genomics, 2014, 15: 582. (*Co-corresponding author)

4.  Hanshuo Zhang, Juan Li, Sha Hou, Gancheng Wang, Mingjun Jiang, Changhong Sun, Xiongbing Hu, Fengfeng Zhuang, Zhifei Dai, Junbiao Dai* and Jianzhong Jeff Xi*, Engineered TAL Effector modulators for the large-scale gain-of-function screening, Nucleic Acids Res., 2014, 42(14): e114 (*Co-corresponding author)

5.  Zhongyu Xie*, Junbiao Dai*, Lunzhi Dai, Minjia Tan*, Zhongyi Cheng, Yeming Wu, Jef D. Boeke, and Yingming Zhao, Lysine succinylation and lysine malonylation in histone, Mol Cell Proteomics, 2012, 11(5):100-7. (*equal contribution)

6.        Jessica S. Dymond, Sarah M. Richardson, Candice E. Coombes, Timothy Babatz, Héloïse Müller, Narayana Annaluru, William J. Blake, Joy Wu Schwerzmann, Junbiao Dai, Derek L. Lindstrom, Annabel C. Boeke, Daniel Gottschling, Srinivasan Chandrasegaran, Joel S. Bader, Jef D. Boeke, Fully synthetic chromosome arms function in yeast and generates phenotypic diversity, Nature, 2011, 477(7365): 471-6

7.        Junbiao Dai, Edel M. Hyland, Anne Norris and Jef D. Boeke, Yin and yang of histone H2B’s role in silencing and longevity: a tale of two arginines, Genetics, 2010, 186(3): 813-828

8.        Junbiao Dai*, Edel M. Hyland*, Daniel S. Yuan, Hailiang Huang, Joel S. Bader and Jef D. Boeke, Probing Nucleosome Function: A Highly Versatile Library of Synthetic Histone H3 and H4 Mutants, Cell, 2008, 134: 1066-1078 (Featured cover story *equal contribution)

9.        Junbiao Dai*, Weiwu Xie*, Troy Brady, Jiquan Gao and Daniel F. Voytas, Phosphorylation regulates Ty5 integration specificity in Saccharomyces cerevisia, Mol Cell, 2007, 27(2): 289-299

(Featured in minireview: Mol. Cell 27:180-181. “Stress management: how cells take control of their transposons” Hirotaka E. and Levin H.L.)

10.    Yunxia Zhu, Junbiao Dai, Peter G. Fuerst and Daniel F. Voytas, Controlling integration specificity of a yeast retrovirus-like element, PNAS, 2003, 100 (10): 5890-5895

(Featured in minireview: PNAS, 2003, 100(10): 5586-5588 "Integration by design" Sandmeyer S.; Cell 2003 115: 135-138 "Targeting Survival: Integration Site Selection by Retroviruses and LTR-Retrotransposons" Bushman F.D.)


Tel: +86-10-62796190
E-mail: jbdai@biomed.tsinghua.edu.cn

Lab webpage: http://www.synyeast.org


Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn